In a field dominated by trends and hashtags, truly transformative science often goes unnoticed. While PRP (platelet-rich plasma) is widely celebrated in aesthetic circles, another molecule has been steadily delivering deep structural change — without the hype. That molecule is PDRN, or polydeoxyribonucleotide.
And at the heart of this movement is Hanna Shabanova, who has made PDRN a central player in her groundbreaking BioLifting Structure™ method.
What Is PDRN?
PDRN is a DNA fragment extracted from salmon sperm, known for its nearly identical compatibility with human DNA sequences. But don’t let the source distract you — this compound is one of the most bioactive, regenerative agents in medical use today.
PDRN’s functions include:
- Accelerating tissue regeneration and angiogenesis
- Stimulating fibroblasts to produce collagen and elastin
- Improving cellular metabolism in aging and damaged skin
- Suppressing inflammatory cytokines linked to photodamage and chronic stress
- Promoting DNA repair and turnover in dermal structures
In other words, PDRN doesn’t cover up signs of aging — it rewrites the biological script beneath the skin.
Why PDRN Matters in Aesthetic Medicine
Unlike hyaluronic acid fillers or mesotherapy, which work on a superficial or volumizing level, PDRN operates at the dermal core — influencing the cellular environment, reversing senescence, and optimizing the skin’s regenerative capacity.
According to Hanna Shabanova, this makes it one of the most underutilized and misunderstood tools in modern practice.
“PDRN doesn’t give you Instagram results in 48 hours,” she says. “It gives you real results in 21 days — skin that actually heals, strengthens, and holds its structure.”
Applications in the BioLifting Structure™ Protocol
Hanna uses PDRN strategically throughout her multi-layered BioLifting method, often in tandem with PRP or threads, depending on the patient’s biological age and tissue quality. Key areas include:
- Sub-ligamentous reinforcement — rebuilding the facial retaining system at its root
- Hypodermal matrix reconditioning — restoring dermal volume and texture over time
- Sensitive skin repair — used post-laser or peel to accelerate healing and minimize inflammation
- Midface recovery zones — where tension loss is typically deepest
Results That Speak for Themselves
In clinical follow-ups from BioLifting patients receiving PDRN:
- Dermal thickness increased by up to 32% (confirmed by ultrasound)
- Skin elasticity improved significantly after just three weeks
- Subjective satisfaction averaged 9.4 out of 10, even among patients previously disappointed with fillers or RF
- Post-inflammatory redness and swelling were reduced in under 72 hours compared to control groups
These outcomes are consistent with growing international research on DNA-based bioactive substances in dermatology and wound care.
Training the Next Generation to Think Molecularly
For Hanna, teaching aesthetic medicine means going beyond needle depth and technique. In her masterclasses and mentorship sessions, she introduces her students to the cellular logic of regeneration.
“You can’t treat what you don’t understand,” she tells her trainees. “And when you understand PDRN, you stop chasing surface solutions — and start building structural outcomes.”
Her teaching includes:
- The molecular cascade triggered by nucleotide signaling
- Histological changes following PDRN delivery
- Dosing patterns based on vascular access and lymphatic flow
- Combining PDRN with PRP for dual-pathway healing
The Future Lies in Molecules, Not Myths
In the quiet, consistent work of polydeoxyribonucleotides, Hanna sees the future of aesthetics — not in reshaping identity, but in restoring cellular integrity.
With BioLifting Structure™, she has created more than a treatment. She’s launched a philosophy rooted in biology, precision, and time.
And for those learning under her guidance, PDRN is no longer just a tool. It’s a language — one that speaks to the skin in its own voice and invites it to heal from within.